Hydrazine → [6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-hydrazine

HRID 2063612Notes

Reaction equation

HRID 2063612 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH3:15])[N:5]=[CH:4][N:3]=1.[NH2:16][NH2:17].C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[CH3:15][O:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:16][NH2:17])[CH:7]=1

Participants

5

Reactant 3

HCID 9321HydrazineHCID 11430Potassium CarbonateHCID 152068354-Chloro-6-(2-methoxyphenyl)pyrimidine

Product 1

HCID 60209698[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-hydrazine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-hydrazine was prepared from 4-Chloro-6-(2-methoxy-phenyl)pyrimidine (2.4 g, 11 mmol), hydrazine (1.3 mL, 43 mmol) and potassium carbonate (2.2 g, 16 mmol) in 25 mL of dioxane by a procedure similar to example 3, step 1 yielding 2.0 g (86%) of a white solid.

Sources & evidence

ORD record
ord-62b1bcdbea6345acb3efe5914e019b3f
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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