p-METHYLACETOPHENONE → N-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-N'-[1-p-tolyl-ethylidene]-hydrazine

HRID 2063619Notes

Reaction equation

HRID 2063619 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][NH2:16])[CH:10]=1.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([CH3:26])=O)=[CH:20][CH:19]=1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:14]=[CH:13][N:12]=[C:11]([NH:15][N:16]=[C:24]([C:21]2[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=2)[CH3:26])[CH:10]=1

Participants

4

Reactant 2

HCID 8500p-METHYLACETOPHENONEHCID 60209698[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-hydrazine

Product 1

HCID 73320075N-[6-(2-Methoxy-phenyl)-pyrimidin-4-yl]-N'-[1-p-tolyl-ethylidene]-hydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from [6-(2-methoxy-phenyl)-pyrimidin-4-yl]-hydrazine (500 mg, 2.3 mmol) and 4-methylacetophenone (310 μL, 2.3 mmol) in 10 mL of ethanol by a procedure similar to example 1, step 4 yielding 302 mg (39%) of a pale solid. HPLC Purity: 91%.

Sources & evidence

ORD record
ord-8d4b2791f958484682bded33eec596ff
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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