p-METHYLACETOPHENONE → HCID 73320087, compound

HRID 2063620Notes

Reaction equation

HRID 2063620 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7]([NH:9][NH2:10])[CH:6]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[N:4]=1)[CH3:2].[CH3:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([CH3:28])=O)=[CH:22][CH:21]=1>C(O)C>[CH2:1]([C:3]1[N:8]=[C:7]([NH:9][N:10]=[C:26]([C:23]2[CH:24]=[CH:25][C:20]([CH3:19])=[CH:21][CH:22]=2)[CH3:28])[CH:6]=[C:5]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 8500p-METHYLACETOPHENONEHCID 60209697HCID 60209697, compound

Product 1

HCID 73320087HCID 73320087, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from [2-ethyl-6-(2-methoxy-phenyl)-pyrimidin-4-yl]-hydrazine (100 mg, 0.41 mmol) and 4-methylacetophenone (55 μL, 0.41 mmol) in 1.0 mL of ethanol by a procedure similar to example 1, step 4 yielding 117 mg (79%) of a yellow solid. HPLC Purity: 95%.

Sources & evidence

ORD record
ord-82a3daf4bccb4de6b6b76582c591b5cb
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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