Methylhydrazine → HCID 60209701, compound

HRID 2063623Notes

Reaction equation

HRID 2063623 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([CH3:14])[N:3]=1.[CH3:15][NH:16][NH2:17].C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[CH3:15][N:16]([C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([CH3:14])[N:3]=1)[NH2:17]

Participants

5

Reactant 3

HCID 6061MethylhydrazineHCID 11430Potassium CarbonateHCID 7961284-Chloro-2-methyl-6-phenylpyrimidine

Product 1

HCID 60209701HCID 60209701, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N-methyl-N-(2-methyl-6-phenyl-pyrimidin-4-yl)-hydrazine was prepared from 4-chloro-2-methyl-6-phenylpyrimidine (500 mg, 2.4 mmol), methylhydrazine (0.52 mL, 9.8 mmol) and potassium carbonate (506 mg, 3.7 mmol) in 5 mL of 1,4 dioxane by a procedure similar to example 3, step 1 yielding 392 mg (75%) of a pale yellow solid.

Sources & evidence

ORD record
ord-2ef578fa8b9340f3ae2343743b6d6ec8
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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