p-METHYLACETOPHENONE → HCID 73319790, compound

HRID 2063624Notes

Reaction equation

HRID 2063624 reaction equation
[CH3:1][N:2]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]=[C:6]([CH3:16])[N:5]=1)[NH2:3].[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([CH3:26])=O)=[CH:20][CH:19]=1>C(O)C>[CH3:1][N:2]([C:4]1[CH:9]=[C:8]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:7]=[C:6]([CH3:16])[N:5]=1)[N:3]=[C:24]([C:21]1[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=1)[CH3:26]

Participants

4

Reactant 2

HCID 8500p-METHYLACETOPHENONEHCID 60209701HCID 60209701, compound

Product 1

HCID 73319790HCID 73319790, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared from N-methyl-N-(2-methyl-6-phenyl-pyrimidin-4-yl)-hydrazine (196 mg, 0.91 mmol) and 4-methylacetophenone (122 μL, 0.91 mmol) in 10 mL of ethanol by a procedure similar to example 8, step 4 yielding 180 mg (60%) of a cream solid. HPLC Purity: 97%.

Sources & evidence

ORD record
ord-3848e393c2484aaebb3f26d6483af3eb
Source dataset
uspto-grants-2012_10
Patent number
US08288398B2

Reaction notes

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