反应详情

温度

50 °C

2 M hydrochloric acid (30 ml) was added to a solution of 1-(1,4-dioxaspiro[4.5]dec-8-yl)-2-phenylethanol (2.98 g, 11.3 mmol) in tetrahydrofuran (30 ml). The solution was stirred at 50° C. overnight. The mixture was rendered alkaline with 4 M sodium hydroxide solution, the phases were separated and the aqueous phase was extracted with methylene chloride (3×20 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

1. customthe phases were separated
2. extractionthe aqueous phase was extracted with methylene chloride (3×20 ml)
3. dry with materialThe combined organic phases were dried with sodium sulfate
4. concentrationconcentrated i