反应详情

温度

140 °C

Potassium phthalimide (702 mg, 3.79 mmol) was added to a solution of DMF (10 mL) containing 2-(iodomethyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran (1.00 g, 3.16 mmol) synthesized in Reference Example 126, and the mixture was stirred at 140° C. for 15 hours. After that, the reaction solution was cooled to room temperature, and water and ethyl acetate were added thereto to separate an organic layer. The organic layer was washed with water and saturated saline, and dried using anhydrous magnesium sulfate, followed by concentration under reduced pressure. The residue was purified by silica gel chromatography (hexane-ethyl acetate 95:5-75:25) to give 730 mg of the title compound (yield: 69%)

1. customsynthesized in Reference Example 126
2. temperatureAfter that, the reaction solution was cooled to room temperature
3. customto separate an organic layer
4. washThe organic layer was washed with water and saturated saline
5. customdried
6. concentrationfollowed by concentration under reduced pressure
7. customThe residue was purified by silica gel chromatography (hexane-ethyl acetate 95:5-75:25)