反应详情

温度

80 °C

A solution of 5-chloro-2-fluoro-4-[(1-methylethyl)oxy]-1-nitrobenzene (D83, 153 mg, 0.65 mmol) in dimethylformamide (5 ml) was treated with 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (130 mg, 0.65 mmol) and diisopropylethylamine (0.113 ml, 0.65 mmol) and stirred at approx. 80° C. for 17 hrs. The mixture was concentrated under vacuum and the residue treated with water and extracted with diethyl ether (×2). The combined extract was dried (MgSO4) and concentrated under vacuum to afford the title compound as a yellow solid (260 mg, 97%).

1. concentrationThe mixture was concentrated under vacuum
2. additionthe residue treated with water
3. extractionextracted with diethyl ether (×2)
4. extractionThe combined extract
5. dry with materialwas dried (MgSO4)
6. concentrationconcentrated under vacuum