Water → HCID 67366001, compound

HRID 2064539Notes

Reaction equation

HRID 2064539 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:32][C:33]1[CH:34]=[C:35]([CH:40]=[CH:41][CH:42]=1)[C:36]([O:38]C)=[O:37])[S:9]([C:12]1[CH:17]=[C:16]([C:18]([NH:20][N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH:22]2[CH3:30])=[O:19])[CH:15]=[CH:14][C:13]=1[Cl:31])(=[O:11])=[O:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Li+].O>C(#N)C.O>[C:1]([O:5][C:6]([N:8]([CH2:32][C:33]1[CH:34]=[C:35]([CH:40]=[CH:41][CH:42]=1)[C:36]([OH:38])=[O:37])[S:9]([C:12]1[CH:17]=[C:16]([C:18]([NH:20][N:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH:22]2[CH3:30])=[O:19])[CH:15]=[CH:14][C:13]=1[Cl:31])(=[O:10])=[O:11])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 68430184HCID 68430184, compound

Product 1

HCID 67366001HCID 67366001, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

Dissolve the compound obtained in Step B (1.14×10−3 mol) in an acetonitrile/water (40 ml/8 ml) mixture. Add lithium hydroxide (1.14×10−2 mol) and heat at 50° C. with stirring. After heating for 2 hours, the reaction mixture is poured into water (100 ml). Extract 3 times with ethyl acetate (50 ml). The organic phase is then washed with water and then with brine, dried over magnesium sulphate, filtered and evaporated to dryness under reduced pressure.

Workup

  1. temperatureAfter heating for 2 hours
  2. extractionExtract 3 times with ethyl acetate (50 ml)
  3. washThe organic phase is then washed with water
  4. dry with materialwith brine, dried over magnesium sulphate
  5. filtrationfiltered
  6. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-4395b1ef0c884b43b706893e9c4d79cc
Source dataset
uspto-grants-2012_10
Patent number
US08288433B2

Reaction notes

Loading…