Hydrochloric Acid → HCID 87372366, compound

HRID 2064543Notes

Reaction equation

HRID 2064543 reaction equation
C(OC([N:8]([CH2:32][C:33]1[CH:51]=[CH:50][C:36]([C:37]([O:39][CH2:40][O:41]/[N:42]=[N+:43](\[O-:49])/[N:44]([CH2:47][CH3:48])[CH2:45][CH3:46])=[O:38])=[CH:35][CH:34]=1)[S:9]([C:12]1[CH:17]=[C:16]([C:18](=[O:30])[NH:19][N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][CH:21]2[CH3:29])[CH:15]=[CH:14][C:13]=1[Cl:31])(=[O:11])=[O:10])=O)(C)(C)C.Cl>O1CCOCC1>[Cl:31][C:13]1[CH:14]=[CH:15][C:16]([C:18](=[O:30])[NH:19][N:20]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH2:22][CH:21]2[CH3:29])=[CH:17][C:12]=1[S:9]([NH:8][CH2:32][C:33]1[CH:34]=[CH:35][C:36]([C:37]([O:39][CH2:40][O:41]/[N:42]=[N+:43](\[O-:49])/[N:44]([CH2:45][CH3:46])[CH2:47][CH3:48])=[O:38])=[CH:50][CH:51]=1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 87452618HCID 87452618, compound

Product 1

HCID 87372366HCID 87372366, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Dissolve the compound obtained in Step C (4.74×10−4 mol) in 1,4-dioxane (5 ml). Place the solution under stirring at ambient temperature and then add 10 ml of a 4N solution of HCl in 1,4-dioxane. The initially yellowish reaction mixture becomes darker and darker until it is virtually black. After stirring for 2 days at ambient temperature, the reaction mixture is evaporated to dryness under reduced pressure. The black residue obtained is chromatographed on a silica column using as eluant a 50/50 n-heptane/ethyl acetate mixture.

Workup

  1. stirringAfter stirring for 2 days at ambient temperature
  2. customthe reaction mixture is evaporated to dryness under reduced pressure
  3. customThe black residue obtained
  4. customis chromatographed on a silica column

Sources & evidence

ORD record
ord-63fa5cff3a9242e795fca4ad973ad907
Source dataset
uspto-grants-2012_10
Patent number
US08288433B2

Reaction notes

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