4-Methylcyclohexanone → 1-(4-Methylcyclohex-1-en-1-yl)pyrrolidine

HRID 2064547Notes

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][CH2:3]1.[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>>[CH3:1][CH:2]1[CH2:7][CH2:6][C:5]([N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:4][CH2:3]1

Participants

Reactant 2

HCID 115254-Methylcyclohexanone

HCID 31268Pyrrolidine

Product 1

HCID 111711671-(4-Methylcyclohex-1-en-1-yl)pyrrolidineYield 99%

Procedure

Following the general methods as outlined under Intermediate 1, starting from 4-methylcyclohexanone, and pyrrolidine, the title compound was isolated in 99% yield (96% purity by HPLC). MS(ESI+): 166.4; MS(ESI−): 164.6.

Sources & evidence

ORD record: ord-9c1808d1a6894312a4417633c257dc6c
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288432B2

Reaction notes

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