Ammonium Hydroxide → HCID 178488084, compound

HRID 2064636Notes

Reaction equation

HRID 2064636 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([NH2:12])[CH:6]=1.[C:13]([O-])(=O)[C@H:14]([CH3:16])[OH:15].[Na+].[OH-].[NH4+]>Cl>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]2[NH:11][C:13]([CH:14]([OH:15])[CH3:16])=[N:12][C:7]=2[CH:6]=1

Participants

5

Reactant 3

HCID 14923Ammonium HydroxideHCID 30851614-Methoxybenzene-1,2-diamine dihydrochlorideHCID 23664767Sodium Lactate, L-

Product 1

HCID 178488084HCID 178488084, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 4-methoxy-phenylenediamine dihydrochloride (10 g), sodium L-lactate (10 g) and hydrochloric acid (60 mL, 4M) was heated at 70° C. for 48 hours. The reaction mixture was cooled to room temperature, then treated with ammonium hydroxide. The resulting precipitate was filtered and dried to give 1-(5-methoxy-1H-benzoimidazol-2-yl)-ethanol (5.14 g).

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationThe resulting precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-7b4899cb2b554c84a1c9264513e63279
Source dataset
uspto-grants-2012_10
Patent number
US08288425B2

Reaction notes

Loading…