Acetamide → HCID 4004288, compound

HRID 2064659Notes

Reaction equation

HRID 2064659 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[CH3:10].[C:11](OCC)(=[O:13])[CH3:12].C(N)(=O)C>CCCCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:11](=[O:13])[CH3:12])=[CH:5][C:4]=1[CH3:10]

Participants

5

Reactant 3

HCID 178AcetamideHCID 8857Ethyl AcetateHCID 672973-Methyl-4-methoxybenzenamine

Product 1

HCID 4004288HCID 4004288, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

By proceeding in a manner similar to Reference Example 33(a) above but using 4-methoxy-3-methyl-phenylamine (2.07 g, Reference Example 30(u)) and subjecting the reaction product to flash chromatography on silica eluting with a mixture of ethyl acetate and n-pentane (1:1, v/v) there was prepared N-4-methoxy-3-methyl-phenyl)-acetamide (2.65 g) as a pale pink crystalline solid. LC-MS (Method J): RT=2.94 minutes, 180.30 (M+H)+.

Sources & evidence

ORD record
ord-4f7308783cc64a6aad09edc5a8236fd4
Source dataset
uspto-grants-2012_10
Patent number
US08288425B2

Reaction notes

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