Thioacetamide → 5-(3-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

HRID 2064698Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)=[O:15]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 57437155Methyl 3-chloro-3-(3-fluorophenyl)-2-oxopropanoate

Product 1

HCID 574371645-(3-Fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl ester

Procedure

prepared by reaction of 3-chloro-3-(3-fluoro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.91 min; [M+H]+=252.1.

Sources & evidence

ORD record: ord-fcc52418e71440aea30dbd04f970bd12
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288435B2

Reaction notes

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