Thioacetamide → 2-Methyl-5-(3,4-difluoro-phenyl)-thiazole-4-carboxylic acid methyl ester

HRID 2064711Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:16])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([F:13])[CH:7]=1.[C:17]([NH2:20])(=[S:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:17]([CH3:18])[S:19][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([F:13])[CH:7]=1)=[O:16]

Participants

Reactant 2

HCID 2723949Thioacetamide

HCID 649004543-Chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester

Product 1

HCID 667037302-Methyl-5-(3,4-difluoro-phenyl)-thiazole-4-carboxylic acid methyl ester

Procedure

prepared by reaction of 3-chloro-3-(3,4-difluoro-phenyl)-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.92 min; [M+H]+=270.3.

Sources & evidence

ORD record: ord-ae22dea99c07432e97e762dd1c33e2fe
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288435B2

Reaction notes

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