Diisopropylethylamine → HCID 67081142, compound

HRID 2064901Notes

Reaction equation

HRID 2064901 reaction equation
CCN(C(C)C)C(C)C.[Cl:10][C:11]1[S:12][C:13]2[C:14](=[C:16]([C:20](Cl)=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:15]=1.[NH2:23][CH2:24][C@@H:25]1[CH2:30][C@H:29]2[C@H:27]([CH2:28]2)[N:26]1[C:31]([C:33]1[N:34]=[C:35]([CH3:45])[S:36][C:37]=1[C:38]1[CH:39]=[C:40]([CH3:44])[CH:41]=[CH:42][CH:43]=1)=[O:32]>C(#N)C>[CH3:45][C:35]1[S:36][C:37]([C:38]2[CH:39]=[C:40]([CH3:44])[CH:41]=[CH:42][CH:43]=2)=[C:33]([C:31]([N:26]2[C@H:25]([CH2:24][NH:23][C:20]([C:16]3[CH:17]=[CH:18][CH:19]=[C:13]4[S:12][C:11]([Cl:10])=[N:15][C:14]=34)=[O:21])[CH2:30][C@H:29]3[C@@H:27]2[CH2:28]3)=[O:32])[N:34]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 189844482-Chloro-1,3-benzothiazole-4-carbonyl chlorideHCID 67081169HCID 67081169, compound

Product 1

HCID 67081142HCID 67081142, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

DIPEA (0.61 mmol) and 2-chloro-benzothiazole-4-carbonyl chloride (0.31 mmol) are added successively to a solution of ((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone (0.31 mmol) in acetonitrile (1.0 mL). The mixture is stirred for 30 min and purified by prep. HPLC to give the desored product. LC-MS (acidic): tR=1.06 min; [M+H]+=523.0.

Workup

  1. custompurified by prep
  2. customHPLC to give the desored product

Sources & evidence

ORD record
ord-9d44cf22d592422eb471fe478ee2a2ca
Source dataset
uspto-grants-2012_10
Patent number
US08288435B2

Reaction notes

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