反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 5-(3-tert-butoxycarbonyl-phenyl)-oxazole-4-carboxylic acid methyl ester (1.00 g, 3.30 mmol) in TFA (13.3 mL) was stirred at rt for 45 min. The TFA was removed under reduced pressure and the residue was triturate in Et2O, filtered and washed with Et2O to give the title compound as a white powder. LC-MS-conditions 02: tR=0.79 min, [M+H]+=248.20.

1. customThe TFA was removed under reduced pressure
2. customthe residue was triturate in Et2O
3. filtrationfiltered
4. washwashed with Et2O