反应详情

温度

85 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 5-(2-methyl-[1,3]dioxolan-2-yl)-2-(3-nitro-pyrazol-1-ylmethyl)-oxazole (23 mg, 0.08 mmol), iron powder (14 mg, 0.25 mmol) and NH4Cl (22 mg, 0.41 mmol) in a mixture of EtOH (1.0 mL) and water (0.5 mL) was stirred at 85° C. for 15 min. The reaction mixture was filtered while hot, dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 02: tR=0.56 min; [M+H]+=251.38.

1. filtrationThe reaction mixture was filtered while hot,
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. customthe solvents were removed under reduced pressure