反应详情

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide (50 mg, 0.112 mmol) in 97% sulfuric acid (0.17 mL) was stirred at rt overnight. The reaction mixture was then poured onto crushed ice, adjusted to pH 9 with NH4OH, and then strongly acidified with HCl 25%. The precipitate was filtered and washed with water until neutral pH. After drying, the title compound was obtained as a beige solid. LC-MS-conditions 02: tR=0.81 min; [M+H]+=420.12.

1. additionThe reaction mixture was then poured
2. customonto crushed ice
3. filtrationThe precipitate was filtered
4. washwashed with water until neutral pH
5. customAfter drying