反应详情

6 N hydrochloric acid (6 mL) was added to 0.42 g of (2S,3aR,7aS)-ethyl octahydro-1H-indole-2-carboxylate (16) and heated to reflux for NLT 4 hours. The mixture was concentrated and dried under vacuum to afford 0.42 g of (2S,3aR,7aS)-octahydro-1H-indole-2-carboxylic acid hydrochloride (5) as a crystalline solid.

1. temperatureheated
2. temperatureto reflux for NLT 4 hours
3. concentrationThe mixture was concentrated
4. customdried under vacuum