反应详情

温度

0 °C

3.45 g (16.4 mmol) of trifluoroacetic anhydride is added to 0.83 ml (14.6 mmol) of acetic acid at 0° C. while leaving the mixture to return to ambient temperature over 2 hours. The mixture is then cooled down to 0° C. and 1.95 g (11.0 mmol) of 2,6-diisopropylphenol is added dropwise. The reaction medium is maintained under stirring for 12 hours before being poured into ice-cooled water. After extraction with dichloromethane, the organic phase is washed with sodium chloride in a saturated aqueous solution before being dried over magnesium sulphate, filtered and concentrated under vacuum. A colourless oil is obtained with a yield of 86%. This product is sufficiently pure to be used directly in the following stage.

1. customwhile leaving the mixture
2. temperatureThe reaction medium is maintained
3. additionbefore being poured into ice-
4. extractionAfter extraction with dichloromethane
5. washthe organic phase is washed with sodium chloride in a saturated aqueous solution
6. dry with materialbefore being dried over magnesium sulphate
7. filtrationfiltered
8. concentrationconcentrated under vacuum
9. customA colourless oil is obtained with a yield of 86%