3-Hydroxyacetophenone → 3-[1-Hydroxy-1-(3-methylphenyl)ethyl]phenol

HRID 2066396Notes

Reaction equation

HRID 2066396 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[C:11]1([CH3:19])[CH:16]=[CH:15][CH:14]=[C:13]([Mg]Cl)[CH:12]=1>O1CCCC1>[OH:10][C:8]([C:4]1[CH:3]=[C:2]([OH:1])[CH:7]=[CH:6][CH:5]=1)([C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH3:19])[CH:12]=1)[CH3:9]

Participants

4

Reactant 2

HCID 84873-HydroxyacetophenoneHCID 178425419HCID 178425419, compound

Product 1

HCID 673875463-[1-Hydroxy-1-(3-methylphenyl)ethyl]phenol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By using 3′-hydroxyacetophenone (200 mg) and a 1 M solution of m-tolylmagnesium chloride in tetrahydrofuran (4.4 ml) as starting materials, the title compound (329.0 mg) was obtained in the same manner as that of Reference Example 69.

Sources & evidence

ORD record
ord-5c2c6b537f004105b562a6d65d56be2d
Source dataset
uspto-grants-2012_10
Patent number
US08293715B2

Reaction notes

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