Trifluoroacetic acid → HCID 66995212, compound

HRID 2066426Notes

Reaction equation

HRID 2066426 reaction equation
C([SiH2]CCOC[N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]3[CH:33]=[CH:32][C:22]([CH2:23][NH:24]C(=O)OC(C)(C)C)=[CH:21][CH:20]=3)[CH:17]=2)[C:12]([C:34]2[CH:35]=[N:36][N:37]([CH3:39])[CH:38]=2)=[N:11]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:39][N:37]1[CH:38]=[C:34]([C:12]2[C:13]3[C:18](=[CH:17][C:16]([C:19]4[CH:33]=[CH:32][C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=4)=[CH:15][CH:14]=3)[NH:10][N:11]=2)[CH:35]=[N:36]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 123929593HCID 123929593, compound

Product 1

HCID 66995212HCID 66995212, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 31A (0.17 g, 0.319 mmol) in CH2Cl2 (4 mL) under argon was treated with trifluoroacetic acid (1 ml, 12.98 mmol), stirred at room temperature for 1 hour, then partitioned between dilute Na2CO3 solution and ethyl acetate (2×). The combined organics were dried (MgSO4), then concentrated to afford the title compound which was used as is in the next step.

Workup

  1. custompartitioned between dilute Na2CO3 solution and ethyl acetate (2×)
  2. dry with materialThe combined organics were dried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-bdbfc527125b4bb7aaf422c9b6d920c4
Source dataset
uspto-grants-2012_10
Patent number
US08293738B2

Reaction notes

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