反应详情

To a solution of 1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidin-4-one (0.2 g, 0.545 mmol) in 1,2-dichloroethane (3 mL) were added cyclopropanemethylamine (71 μL, 0.812 mmol) and sodium triacetoxyborohydride (0.15 g, 0.71 mmol). The resulting suspension was stirred at RT for 17 h, then diluted with water and DCM. The aqueous layer was separated and extracted with DCM. The combined organic layers were dried (Na2SO4), then concentrated in vacuo to give the title compound as an off-white solid (0.10 g, 44%).

1. customThe aqueous layer was separated
2. extractionextracted with DCM
3. dry with materialThe combined organic layers were dried (Na2SO4)
4. concentrationconcentrated in vacuo