1,1'-Carbonyldiimidazole → HCID 86649580, compound

HRID 2066795Notes

Reaction equation

HRID 2066795 reaction equation
[CH:1]1[N:5]=[CH:4][N:3]([C:6]([N:8]2[CH:12]=[N:11][CH:10]=[CH:9]2)=[O:7])[CH:2]=1.[F:13][C:14]([C:17]1[N:22]=[C:21]([C:23]2[S:27]C(N)=NC=2C)[CH:20]=[CH:19][N:18]=1)([CH3:16])[CH3:15]>C(Cl)Cl>[F:13][C:14]([C:17]1[N:22]=[C:21]([C:23]2[S:27][C:4]([NH:3][C:6]([N:8]3[CH:9]=[CH:10][N:11]=[CH:12]3)=[O:7])=[N:5][C:1]=2[CH3:2])[CH:20]=[CH:19][N:18]=1)([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 58095737HCID 58095737, compound

Product 1

HCID 86649580HCID 86649580, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

CDI (0.10 g) was added to a stirred solution of 5-[2-(1-fluoro-1-methyl-ethyl)-pyrimidin-4-yl]-4-methyl-thiazol-2-ylamine (Step 9.2) (0.15 g) in CH2Cl2 (4 mL) at rt. The reaction mixture was then stood for 56 h at 25° C. and the title compound isolated by filtration.

Sources & evidence

ORD record
ord-6cf9ffbf96b74d2c8a40dd24af6e097f
Source dataset
uspto-grants-2012_10
Patent number
US08293753B2

Reaction notes

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