反应详情

1.5 g of 69a was taken up with isopropanol (10 mL) and 1 mL of concentrated HCl. The mixture was stirred at room temperature for 3 h, then 1 mL of concentrated HCl was added and the mixture was stirred at 50° C., cooled to room temperature and 10 mL of ether was added. The mixture was cooled to −78° C., filtered; and the solid was washed with ether to yield 0.6 g of solid 70a as an HCl salt.

1. stirringthe mixture was stirred at 50° C.
2. temperaturecooled to room temperature
3. temperatureThe mixture was cooled to −78° C.
4. filtrationfiltered
5. washand the solid was washed with ether