1H-Pyrrolo(2,3-b)pyridine → HCID 69081056, compound

HRID 2066936Notes

Reaction equation

[CH2:1]([S:8](C1(C2C3C(=NC=CC=3)NC=2)C2C(=CC=CC=2)C(Br)=CN1)(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:31]1[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][N:38]=2)[CH:33]=[CH:32]1.[Br:40][C:41]1[C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH:44]=[N:43][CH:42]=1>>[CH2:1]([S:8]([N:43]1[CH:42]=[C:41]([Br:40])[C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH:44]1[C:33]1[C:34]2[C:39](=[N:38][CH:37]=[CH:36][CH:35]=2)[NH:31][CH:32]=1)(=[O:10])=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 92221H-Pyrrolo(2,3-b)pyridine

HCID 737434-Bromoisoquinoline

HCID 86633779HCID 86633779, compound

Product 1

HCID 69081056HCID 69081056, compoundYield 61%

Procedure

2(benzylsulfonyl-1-(7-aza-1H-indol-3-yl)-4-bromo-1,2-dihydroisoquinoline: Following the procedure of Example 1, 29.54 mg (0.25 mmol) of 7-azaindole was treated with 104.03 mg (0.5 mmole) of 4-bromoisoquinoline and 47.67 mg (0.25 mmol) of α-phenylmethylsulphonyl chloride to yield 71.98 mg (61% Yield) of 2(benzylsulfonyl)-1-(7-aza-1H-indol-3-yl)-4-bromo-1,2-dihydroisoquinoline.

Sources & evidence

ORD record: ord-2c06804112a740ad98b6f29da2a7b554
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08293764B2

Reaction notes

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