Chlorotrimethylsilane → HCID 21079666, compound

Temperature

-78 °C

step 1—To a solution of di-iso-propylamine (150 mL, 108.3 g, 1.07 mol) in THF (500 mL) cooled to −78° C. and maintained under a N2 atmosphere was added over 1 15 min period, n-BuLi (100 mL, 1.00 mol, 10M in hexanes). The resulting mixture was stirred for 30 min at −78° C. A mixture of 23a (45 mL, 52.110 g, 0.457 mol) and chlorotrimethylsilane (130.0 mL, 111.28 g, 1.024 mol) was added at a rate which maintained the internal reaction temperature below −50° C. The solution was stirred at −78° C. for 1 h. The reaction was quenched at −78° C. by addition of 1M H2SO4, diluted with MTBE and the mixture was saturated with solid NaCl. The phases were separated and the aqueous phase was extracted with MTBE (300 mL). The combined organic extracts were dried (MgSO4), filtered and the solvents evaporated to afford 118 g (100%) of 23b as a white solid.

1. temperaturemaintained under a N2 atmosphere
2. additionwas added at a rate which
3. temperaturemaintained the internal reaction temperature below −50° C
4. stirringThe solution was stirred at −78° C. for 1 h
5. customThe reaction was quenched at −78° C. by addition of 1M H2SO4
6. additiondiluted with MTBE
7. customThe phases were separated
8. extractionthe aqueous phase was extracted with MTBE (300 mL)
9. dry with materialThe combined organic extracts were dried (MgSO4)
10. filtrationfiltered
11. customthe solvents evaporated

ORD record

ord-c45c75aecb1147d186f56200852fd8f4

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08293778B2