Potassium Carbonate → HCID 58677657, compound

HRID 2067191Notes

Reaction equation

HRID 2067191 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si](C)(C)C)[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].C([O-])([O-])=O.[K+].[K+].CCOC(C)=O.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[CH:26])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 22728543Water ethylacetateHCID 67314552HCID 67314552, compound

Product 1

HCID 58677657HCID 58677657, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of compound 406 (426 mg, 0.94 mmol) and K2CO3 (195 mg, 1.41 mmol) in methanol (4.0 mL) were stirred at RT for 5 h. The reaction mixture was poured into a mixture of EtOAc/water. The organic phase was washed with water, brine and then dried (MgSO4), filtered and concentrated in vacuo to give the crude title compound. The product was used without any further purification.

Workup

  1. washThe organic phase was washed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-eb3c9c38724444e588cf6e4b06ea2a11
Source dataset
uspto-grants-2012_10
Patent number
US08293772B2

Reaction notes

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