Iodoethane → HCID 58031403, compound

HRID 2067355Notes

Reaction equation

HRID 2067355 reaction equation
[CH2:1](Br)[C:2]1C=CC=CC=1.ICC.[CH3:12][C:13]1[N:14]=[C:15]([N:23]2[CH2:27][CH2:26][NH:25][C:24]2=[O:28])[S:16][C:17]=1[C:18]([O:20][CH2:21][CH3:22])=[O:19]>>[CH2:1]([N:25]1[CH2:26][CH2:27][N:23]([C:15]2[S:16][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:13]([CH3:12])[N:14]=2)[C:24]1=[O:28])[CH3:2]

Participants

4

Reactant 3

HCID 6340IodoethaneHCID 7498Benzyl BromideHCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 58031403HCID 58031403, compoundYield 58%

Procedure

Following the procedure as described in Example 5, making variations to replace benzyl bromide with iodoethane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 58% yield: 1H NMR (300 MHz, CDCl3) δ 4.29-4.04 (m, 4H), 3.64-3.33 (m, 4H), 2.63 (s, 3H), 1.38-1.05 (m, 6H); MS (ES+) m/z 284.3 (M+1).

Sources & evidence

ORD record
ord-7190db687aff4b7d87772878e74d7912
Source dataset
uspto-grants-2012_10
Patent number
US08293768B2

Reaction notes

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