Benzyl Bromide → HCID 58031565, compound

HRID 2067356Notes

Reaction equation

[CH2:1](Br)[C:2]1C=CC=C[CH:3]=1.ICCC.[CH3:13][C:14]1[N:15]=[C:16]([N:24]2[CH2:28][CH2:27][NH:26][C:25]2=[O:29])[S:17][C:18]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH3:13][C:14]1[N:15]=[C:16]([N:24]2[CH2:28][CH2:27][N:26]([CH2:1][CH2:2][CH3:3])[C:25]2=[O:29])[S:17][C:18]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

Reactant 3

HCID 7498Benzyl Bromide

HCID 336431-Iodopropane

HCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 58031565HCID 58031565, compoundYield 60%

Procedure

Following the procedure as described in Example 5, making variations to replace benzyl bromide with 1-iodopropane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 60% yield: 1H NMR (300 MHz, CDCl3) δ 4.18 (q, J=7.2 Hz, 2H), 4.07-3.94 (m, 2H), 3.53-3.48 (m, 2H), 3.20 (t, J=7.2 Hz, 2H), 2.52 (s, 3H), 1.58-1.46 (m, 2H), 1.24 (t, J=7.2 Hz, 3H), 0.82 (t, J=7.2 Hz, 3H); MS (ES+) m/z 298.3 (M+1).

Sources & evidence

ORD record: ord-1edc826ffe6d4944b3916fb3a693c4b1
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08293768B2

Reaction notes

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