Hydrochloric Acid → HCID 131730039, compound

HRID 2068007Notes

Reaction equation

HRID 2068007 reaction equation
[CH2:1]([S:4]([CH2:7][C:8]1[N:9]=[C:10]([NH:13]C(=O)OC(C)(C)C)[S:11][CH:12]=1)(=[O:6])=[O:5])[CH2:2][CH3:3].[ClH:21]>O1CCOCC1>[ClH:21].[CH2:1]([S:4]([CH2:7][C:8]1[N:9]=[C:10]([NH2:13])[S:11][CH:12]=1)(=[O:5])=[O:6])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 87536609HCID 87536609, compound

Product 1

HCID 131730039HCID 131730039, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
40 °C

Procedure

To a solution of tert-butyl 4-(propylsulfonylmethyl)thiazol-2-ylcarbamate (16 mmol) in 1,4-dioxane (25 mL) was added 4N HCl in 1,4-dioxane (300 mL) and was stirred for 4 hours at 40° C. Removal of the volatiles afforded 4-(propylsulfonylmethyl)thiazol-2-amine HCl-salt (3.99 g, quant. yield) as a crème-colored solid.

Workup

  1. customRemoval of the volatiles

Sources & evidence

ORD record
ord-b20fa92b85c040bbb1ede74fbd35efb8
Source dataset
uspto-grants-2012_10
Patent number
US08293919B2

Reaction notes

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