Trifluoroacetic acid → HCID 85911586, compound

HRID 2068071Notes

Reaction equation

HRID 2068071 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C.C([SiH](CC)CC)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

Product 1

HCID 85911586HCID 85911586, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (20 ml) was added to a mixture of 4-(tert-butoxycarbonyl)-1-(2-fluoroethyl)piperazine (3.7 g), triethylsilane (8 ml) and methylene chloride (100 ml) and the resultant mixture was stirred at ambient temperature for 1.5 hours. The mixture was evaporated and the residue was triturated under diethyl ether. The solid so obtained was isolated, washed with diethyl ether and dried to give 1-(2-fluoroethyl)piperazine trifluoroacetic acid salt (6.0 g) as a solid.

Workup

  1. customThe mixture was evaporated
  2. customthe residue was triturated under diethyl ether
  3. customThe solid so obtained
  4. customwas isolated
  5. washwashed with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-4dbc69edb47747999880f89f5af79ec6
Source dataset
uspto-grants-2012_10
Patent number
US08293902B2

Reaction notes

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