反应详情

4-(4-Chloro-1,2-diphenyl-but-1-enyl)phenol (0.33 g, 0.001 mol) was dissolved in tetrahydrofuran (3 ml) under a nitrogen atmosphere. Sodium hydride (0.036 g, 0.0015 mol) was added to the solution and the mixture was stirred at room temperature for an hour. 2-[2-(2-iodo-ethoxy)-ethoxy)-tetrahydropyran (0.6 g, 0.002 mol) was added and the mixture was refluxed for 3 hours. After cooling and adding water the mixture was extracted three times with ethyl acetate. The organic phase was dried with sodium sulphate and evaporated to dryness. The residue was used in the next reaction step without further purification.

1. temperaturethe mixture was refluxed for 3 hours
2. temperatureAfter cooling
3. extractionwas extracted three times with ethyl acetate
4. dry with materialThe organic phase was dried with sodium sulphate
5. customevaporated to dryness
6. customThe residue was used in the next reaction step without further purification