Hydrochloric Acid → HCID 24798638, compound

HRID 2068277Notes

Reaction equation

HRID 2068277 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14](COCC[Si](C)(C)C)[N:13]=[C:12]2[NH:26][C:27]1[N:31]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:30]2[CH:38]=[CH:39][C:40]([CH2:42][OH:43])=[CH:41][C:29]=2[N:28]=1.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[NH:26][C:27]1[N:31]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:30]2[CH:38]=[CH:39][C:40]([CH2:42][OH:43])=[CH:41][C:29]=2[N:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67253031HCID 67253031, compound

Product 1

HCID 24798638HCID 24798638, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of (2-(5-(4-methoxypyridin-3-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-phenyl-1H-benzo[d]imidazol-5-yl)methanol (0.024 g, 0.000040 mol) and 0.03 M HCl (1 mL,) in ethanol (3 mL) was heated at 100° C. for 2 hours. The reaction was concentrated and the residue was dissolved in DMSO and purified by HPLC.

Workup

  1. concentrationThe reaction was concentrated
  2. dissolutionthe residue was dissolved in DMSO
  3. custompurified by HPLC

Sources & evidence

ORD record
ord-d8650f12f42c4870bf6db31f75cfadbc
Source dataset
uspto-grants-2012_10
Patent number
US08293923B2

Reaction notes

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