Hydrochloric Acid → HCID 24798639, compound

HRID 2068290Notes

Reaction equation

HRID 2068290 reaction equation
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([CH2:16][N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[CH:15][C:10]=3[N:9]=[C:8]2[NH:23][C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:33]4[CH:34]=[N:35][CH:36]=[CH:37][C:38]=4[O:39][CH3:40])[CH:31]=3)[N:26](COCC[Si](C)(C)C)[N:25]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.C(O)C>>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([CH2:16][N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[CH:15][C:10]=3[N:9]=[C:8]2[NH:23][C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:33]4[CH:34]=[N:35][CH:36]=[CH:37][C:38]=4[O:39][CH3:40])[CH:31]=3)[NH:26][N:25]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 67253544HCID 67253544, compound

Product 1

HCID 24798639HCID 24798639, compound

Conditions

Temperature
78 °C

Procedure

A mixture of (1-cyclohexyl-5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-[5-(4-methoxy-pyridin-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-3-yl]-amine (15 mg, 0.000022 mol), hydrogen chloride (300 uL, 0.01 mol) and ethanol (1.2 mL, 0.020 mol) in a 5 mL test tube with a septum cover was heated at 78° C. for 2 hours. The reaction mixture was concentrated and purified by HPLC to yield 1.5 mg after lyopholizaion.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by HPLC
  3. customto yield 1.5 mg after lyopholizaion

Sources & evidence

ORD record
ord-481599a1ee3d4ed0a6215cc04f56641c
Source dataset
uspto-grants-2012_10
Patent number
US08293923B2

Reaction notes

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