Hydrochloric Acid → HCID 178489279, compound

HRID 2068296Notes

Reaction equation

HRID 2068296 reaction equation
[Si]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]([NH:26][CH:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[O:25])=[CH:23][C:18]=3[N:17]=[C:16]2[NH:32][C:33]2[C:41]3[C:36](=[CH:37][CH:38]=[C:39]([C:42]4[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=4[O:48][CH3:49])[CH:40]=3)[N:35](COCC[Si](C)(C)C)[N:34]=2)[CH2:11][CH2:10]1)(C(C)(C)C)(C)C.Cl>C(O)C>[CH3:49][O:48][C:43]1[CH:44]=[CH:45][CH:46]=[CH:47][C:42]=1[C:39]1[CH:40]=[C:41]2[C:36](=[CH:37][CH:38]=1)[NH:35][N:34]=[C:33]2[NH:32][C:16]1[N:15]([C@H:12]2[CH2:11][CH2:10][C@H:9]([OH:8])[CH2:14][CH2:13]2)[C:19]2[CH:20]=[CH:21][C:22]([C:24]([NH:26][CH:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[O:25])=[CH:23][C:18]=2[N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67255144HCID 67255144, compound

Product 1

HCID 178489279HCID 178489279, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
78 °C

Procedure

A mixture of 1-(4-(tert-butyldimethylsilyloxy)cyclohexyl)-N-cyclopentyl-2-(5-(2-methoxyphenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazole-5-carboxamide (15 mg, 0.000018 mol), HCl (300 uL, 0.01 M) and ethanol (1.2 mL) was heated at reflux 78° C. for 2 hours. The mixture was concentrated and purified by HPLC. The product fractions were lyopholized to yield the title compound.

Workup

  1. temperaturewas heated
  2. concentrationThe mixture was concentrated
  3. custompurified by HPLC

Sources & evidence

ORD record
ord-d38e7fb1c45144839f3a9d0c7fc0bd18
Source dataset
uspto-grants-2012_10
Patent number
US08293923B2

Reaction notes

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