Hydrochloric Acid → HCID 24797390, compound

HRID 2068304Notes

Reaction equation

HRID 2068304 reaction equation
C([SiH2][O:6][C:7](C)(C)[C:8]1[CH:48]=[CH:47][C:11]2[N:12]([CH:41]3[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]3)[C:13]([NH:15][C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[C:22]([C:25]5[CH:26]=[N:27][CH:28]=[CH:29][C:30]=5[O:31][CH3:32])[CH:23]=4)[N:18](COCC[Si](C)(C)C)[N:17]=3)=[N:14][C:10]=2[CH:9]=1)(C)(C)C.Cl>C(O)C>[CH:41]1([N:12]2[C:11]3[CH:47]=[CH:48][C:8]([CH2:7][OH:6])=[CH:9][C:10]=3[N:14]=[C:13]2[NH:15][C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([C:25]4[CH:26]=[N:27][CH:28]=[CH:29][C:30]=4[O:31][CH3:32])[CH:23]=3)[NH:18][N:17]=2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178493106HCID 178493106, compound

Product 1

HCID 24797390HCID 24797390, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of [5-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cyclohexyl-1H-benzoimidazol-2-yl]-[5-(4-methoxy-pyridin-3-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-3-yl]-amine (from Step 6) and 12 M HCl (2.0 mL) in ethanol (6.0 mL) was heated at 100° C. for 1 hr. The mixture was evaporated to dryness and then purified twice by preparative HPLC to yield 4.1 mg of the title compound as the TFA salt.

Workup

  1. customThe mixture was evaporated to dryness
  2. custompurified twice by preparative HPLC

Sources & evidence

ORD record
ord-dc11c227aec048089931ad37ee28a826
Source dataset
uspto-grants-2012_10
Patent number
US08293923B2

Reaction notes

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