Isopropanol → Doxorubicin

HRID 2068438Notes

Reaction equation

HRID 2068438 reaction equation
[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39].Cl.C(O)(C)C.[Cl-].[Cl-].[Ca+2]>C(CNC(CO)(CO)CO)CNC(CO)(CO)CO>[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 443939Doxorubicin HydrochlorideHCID 5284359Calcium Chloride

Product 1

HCID 31703Doxorubicin

Reagents, catalysts & solvents 1

HCID 125132Bis-tris propaneSolvent

Procedure

The core fluid solution were prepared by mixing doxorubicin hydrochloride, or DOXO in about 10 mM Bis-Tris propane aqueous solution containing about 1 wt % of isopropanol and about 2 mM of CaCl2. The final concentration of DOXO in the core fluid solution was about 1,000 μg/mL.

Workup

  1. customThe core fluid solution were prepared

Sources & evidence

ORD record
ord-08e7aa230b3943d99a48d283161b3d03
Source dataset
uspto-grants-2012_10
Patent number
US08297959B2

Reaction notes

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