反应详情

1.170 g (23 mmol) of hydrazine hydrate were added to a solution of 5 g (21 mmol) of methyl 4-oxo-3-(pyridin-2-ylcarbonyl)pentanoate in ethanol (50 ml). The mixture was heated at reflux for 7 hours, added to water and extracted with ethyl acetate. The combined organic phases were dried with magnesium sulfate, filtrered and concentrated. This gave 2.290 g of product (41.9% of theory).

1. temperatureThe mixture was heated
2. temperatureat reflux for 7 hours
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic phases were dried with magnesium sulfate
5. concentrationconcentrated