Trifluoroacetic acid → HCID 59238162, compound

HRID 2068566Notes

Reaction equation

HRID 2068566 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([CH2:23][C:24]([O:26]C(C)(C)C)=[O:25])[CH:18]=[CH:17]3)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:11]1([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([CH2:23][C:24]([OH:26])=[O:25])[CH:18]=[CH:17]3)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59238195HCID 59238195, compound

Product 1

HCID 59238162HCID 59238162, compoundYield 205%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(1-tert-butoxycarbonylmethyl-1H-indol-5-yl)-piperazine-1-carboxylic acid tert-butyl ester (8.80 g) was treated with a mixture of 60 mL of TFA in 120 mL of methylene chloride overnight at room temperature. At this time, the solvent was removed in vacuo. This resulted in 11.26 g of a light yellow residue. This residue was used without further purification in the next step.

Workup

  1. customAt this time, the solvent was removed in vacuo

Sources & evidence

ORD record
ord-4f65ea4dba454cf894dd9646b444285a
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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