Trifluoroacetic acid → HCID 67211910, compound

HRID 2068577Notes

Reaction equation

HRID 2068577 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[NH:19][C:18](=[O:20])[C:17]3[N:21]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH:22]=[N:23][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:28]([O:27][C:25](=[O:26])[CH2:24][N:21]1[C:17]2[C:18](=[O:20])[NH:19][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:15][C:16]=2[N:23]=[CH:22]1)[CH3:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67211599HCID 67211599, compound

Product 1

HCID 67211910HCID 67211910, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-(3-ethoxycarbonylmethyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester, 4 was dissolved in dry methylene chloride at room temperature under N2. CF3COOH (5 equiv.) was added, and the reaction mixture was stirred for 1.5 h. Then methylene chloride was removed in vacuo and the residue was used in the next step without further purification.

Workup

  1. customThen methylene chloride was removed in vacuo
  2. customthe residue was used in the next step without further purification

Sources & evidence

ORD record
ord-7ab87294671f416bbf71b8b5c6d7f870
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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