HCID 59238209, compound → HCID 59238190, compound

HRID 2068582Notes

Reaction equation

HRID 2068582 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][N:6]1[C:14]2[C:9](=[N:10][C:11]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[N:12][C:13]=2Cl)[N:8]=[CH:7]1)[CH3:2]>CO.[Pt]>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][N:6]1[C:14]2[C:9](=[N:10][C:11]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)=[N:12][CH:13]=2)[N:8]=[CH:7]1)[CH3:2]

Participants

4

Reactant 1

HCID 59238209HCID 59238209, compound

Product 1

HCID 59238190HCID 59238190, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1.47 g of (6-chloro-2-piperazin-1-yl-purin-7-yl)-acetic acid ethyl ester, 5 in 100 mL of methanol, was added 400 mg of 10% Pt/C and 1.1 g MgO under N2, then the reaction was hydrogenated for 4 h. The catalyst and MgO were filtered and washed with methanol. Evaporation of the methanol in vacuo gave 6.

Workup

  1. filtrationThe catalyst and MgO were filtered
  2. washwashed with methanol
  3. customEvaporation of the methanol in vacuo
  4. customgave 6

Sources & evidence

ORD record
ord-e52365591eb14521b1af7ee920f758aa
Source dataset
uspto-grants-2012_10
Patent number
US08299023B2

Reaction notes

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