Pyridine → HCID 11710500, compound

HRID 2068856Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:7]=[C:6]([CH:16]([CH3:18])[CH3:17])[C:5]=1[NH2:19])([CH3:3])[CH3:2].N1C=CC=CC=1.[CH:26]1([CH2:31][C:32](Cl)=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27]1>O1CCCC1.C(OCC)(=O)C>[CH:26]1([CH2:31][C:32]([NH:19][C:5]2[C:6]([CH:16]([CH3:18])[CH3:17])=[CH:7][C:8]([N:10]3[CH2:11][CH2:12][O:13][CH2:14][CH2:15]3)=[CH:9][C:4]=2[CH:1]([CH3:3])[CH3:2])=[O:33])[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of 2,6-diisopropyl-4-morpholin-4-yl-phenylamine (279 mg) and pyridine (245 μL) in tetrahydrofuran (2 mL) was added cyclopentylacetyl chloride (210 μL) and the mixture was stirred for 1 hour at 25° C. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with 10% aqueous sodium bicarbonate (20 mL) and brine (20 mL). The organic phase was dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography. Recrystallisation of the crude brown material from hot ethyl acetate/heptane furnished 122 mg (33%) of the title compound as a white solid. LC-MS (m/z) 373 (MH+); tR=2.58, (UV, ELSD) 98%, 99%. 1H NMR (500 MHz, CDCl3): 1.19 (d, 12H), 1.27 (m, 2H), 1.60 (m, 2H), 1.68 (m, 2H), 1.93 (m, 2H), 2.40 (m, 1H), 2.41 (m, 2H), 3.05 (m, 2H), 3.17 (m, 4H), 3.87 (m, 4H), 6.49 (s, 1H), 6.70 (s, 2H).

Workup

washwashed with 10% aqueous sodium bicarbonate (20 mL) and brine (20 mL)
dry with materialThe organic phase was dried over sodium sulfate
concentrationconcentrated in vacuo
custompurified by flash chromatography
customRecrystallisation of the crude brown material from hot ethyl acetate/heptane

Sources & evidence

ORD record: ord-6c51966af5bb426fabca9b84384e4742
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08299075B2

Reaction notes

Loading…