反应详情

温度

40 °C

Sodium cyanide (3.4 g; WAKO) was added to a DMSO (100 mL) solution of Intermediate 2 (16.3 g) at room temperature and the resulting mixture was stirred at 40° C. for 1 hour and 40 minutes. Ethyl acetate (300 mL) and saturated aqueous sodium bicarbonate solution (150 mL), and water (150 mL) were added to extract the reaction mixture, the reaction mixture was washed with saturated brine (300 mL), the organic layer was dried, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate) to give the title compound (11.37 g).

1. extractionto extract the reaction mixture
2. washthe reaction mixture was washed with saturated brine (300 mL)
3. customthe organic layer was dried
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate)