反应详情

Triethylamine (0.137 mL) was added to a dichloromethane (5 mL) solution of Intermediate 7 (100 mg) and p-toluenesulfonic acid chloride (66 mg; WAKO) at room temperature and the resulting mixture was stirred as it was for 15 hours. The resulting mixture was diluted with dichloromethane and washed with water, the organic layer was dried, then the solvent was evaporated under reduced pressure, and the residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate) to give the title compound (92.9 mg).

1. washwashed with water
2. customthe organic layer was dried
3. customthe solvent was evaporated under reduced pressure
4. customthe residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate)