Hydroxide → tert-butyl 2-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylcarbamoyl)morpholine-4-carboxylate
Reaction equation
[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH2:11].[C:13]([CH3:14])([CH3:15])([CH3:16])[O:17][C:18](=[O:19])[N:20]1[CH2:21][CH:22]([C:26](=[O:27])[OH:28])[O:23][CH2:24][CH2:25]1.[CH3:29][CH2:30][N:31]([CH2:32][CH3:33])[CH2:34][CH3:35].[Cl:38][CH2:39][Cl:40].[Li+:37].[OH-:36].[OH2:41]>>[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH:11][C:26]([CH:22]1[CH2:21][N:20]([C:18]([O:17][C:13]([CH3:14])([CH3:15])[CH3:16])=[O:19])[CH2:25][CH2:24][O:23]1)=[O:27]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-29730657d9284454ad50b8921dcf9055
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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