反应详情

4-Cyanostyrene is transformed to the corresponding hydroxyamidine according to literature procedures using hydroxylamine hydrochloride and NaHCO3 as base (e.g. E. Meyer, A. C. Joussef, H. Gallardo, Synthesis 2003, 899-905); LC-MS: tR=0.55 min; [M+H]+=163.04; 1H NMR (D4-methanol): δ 4.86 (s br, 3H), 5.30 (d, J=11.0 Hz, 1H), 5.85 (d, J=17.6 Hz, 1H), 6.77 (dd, J=17.6, 10.8 Hz, 1H), 7.48 (d, J=8.3 Hz, 2H), 7.63 (d, J=8.0 Hz, 2H).

1. customGallardo, Synthesis 2003, 899-905)