HCID 2755516, compound → HCID 14520121, compound

HRID 2070106Notes

Reaction equation

HRID 2070106 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([N+:11]([O-])=O)[CH:5]=1>C(O)C.[Pt](=O)=O>[NH2:11][C:6]1[CH:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:9]=[CH:8][C:7]=1[OH:10]

Participants

4

Reactant 1

HCID 2755516HCID 2755516, compound

Product 1

HCID 14520121HCID 14520121, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[(methyloxy)methyl]-2-nitrophenol D55 (0.72 g, 3.93 mmol) and platinum (IV) oxide (0.089 g, 0.393 mmol) in ethanol (15 mL) was stirred under an atmosphere of hydrogen for 16 hr. The catalyst was removed by filtration through celite and the filtrate concentrated to dryness in vacuo to afford the title compound as a green/brown solid 0.51 g, 85%.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe filtrate concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-97aab45c82044a51ac7c17f4ffd6690d
Source dataset
uspto-grants-2012_10
Patent number
US08299257B2

Reaction notes

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