反应详情

To a stirred solution of methyl 3-amino-4-ethylbenzoate (6.10 g) in THF (56.7 mL) at room temperature was added Hunig's Base (11.89 mL) followed by bromoacetonitrile (4.74 mL). The mixture was heated at reflux for 16 h. The reaction was cooled to room temperature and concentrated in vacuo. 1N aqueous HCl and DCM were added. The organic layer was separated, dried (MgSO4) and concentrated to give the subtitle compound as an oil (7.46 g).

1. temperatureThe mixture was heated
2. temperatureat reflux for 16 h
3. concentrationconcentrated in vacuo
4. addition1N aqueous HCl and DCM were added
5. customThe organic layer was separated
6. dry with materialdried (MgSO4)
7. concentrationconcentrated